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 LONGRANGE™ (eprinomectin), from Merial, is the first extended-release injectable cattle dewormer that provides cattle producers season-long persistent parasite control for 100 to 150 days in a single dose, dependent on parasite species.1 The parasite protection LONGRANGE provides lasts long enough to break the parasite life cycle and reduce parasite burdens on the pasture.2,3 It takes about 100 days of continuous parasite control to break the parasite life cycle and begin to reduce the parasite burden on the pasture.2,3 The resulting benefit of breaking the parasite life cycle is better-performing cattle throughout the grazing season and pastures with lower parasite loads. “LONGRANGE gives cattle producers a new way to think about parasite control,” says Joe Dedrickson, DVM, Ph.D., director of Merial field veterinary services. “Instead of treating cattle up to three to four times during the grazing season, which is what would be required from conventional dewormers, LONGRANGE gives cattle producers the option of a single treatment that will last all season. This means less labor for producers and less cattle stress and shrink.” THERAPHASE™ Technology The season-long persistent parasite control of LONGRANGE is possible because of unique THERAPHASE Technology.4 THERAPHASE Technology releases the active ingredient in LONGRANGE for an extended period after injection (at least 100 days).4 “THERAPHASE Technology creates one initial therapeutic peak of LONGRANGE quickly following the injection,” explains Dr. Dedrickson. “Beginning about 70 days after the injection, the THERAPHASE Technology releases a second burst of eprinomectin, the active ingredient in LONGRANGE. This creates a second peak of LONGRANGE and is what helps provide producers season-long control.” LONGRANGE offers excellent efficacy against economically important parasites and hard-to-kill parasites.4,5 “The short amount of time LONGRANGE stays at sub-therapeutic levels, helps ensure the product does not select for resistance any more than products currently on the market,” explains Dr. Dedrickson. Impact of Parasite Control Practices Of all the animal health practices used for increasing production, treating beef cows for parasites gives the greatest economic return of up to $201 per head.6 This includes improved reproduction and earlier calving, leading to earlier weight gain in calves.6 Studies have shown cattle treated with LONGRANGE gain more weight than control cattle.7 At seven study sites, weight gain was measured before treatment and at study day 120.7 At six of the seven study sites, the difference in weight gain was statistically significant.7 Prescribing Practices LONGRANGE has all the benefits of a complicated and expensive strategic parasite control program in a single spring dose of 1 mL/110 lbs. of body weight.4 When given at the recommended dose volume, LONGRANGE is effective in the treatment and control of the following internal and external parasites of cattle:

LONGRANGE is effective for at least 100 and up to 150 days (dependent upon parasite species) against eight economically important species of parasites.1,8,9 A series of studies confirmed that LONGRANGE effectively breaks the parasitic life cycle and kills adult and larval parasites.2,3,9 LONGRANGE is a prescription drug and should be given only by subcutaneous injection in front of the shoulder at the recommended dose. Producers using the 50- mL product should administer using only polypropylene syringes. Those using LONGRANGE from the 250- or 500-mL bottles should administer using only automatic dosing syringes provided by Merial. LONGRANGE is available in 500-, 250- and 50-mL sizes. The 500-, 250- and 50-mL bottles contain sufficient solution to treat 100, 50 and 10 head of 550-lb. cattle, respectively. Each 250- and 500-mL bottle is manufactured with an individual plastic bottle protector to reduce the risk of breakage during shipping and everyday use. The bottom of the bottle protector has a convenient built-in chute-side hanger. For more information and to find out how LONGRANGE can fit into your deworming program, visit www.theLONGRANGElook.com. IMPORTANT SAFETY INFORMATION: Do not treat within 48 days of slaughter. Not for use in female dairy cattle 20 months of age or older, including dry dairy cows, or in veal calves. Post-injection site damage (e.g., granulomas, necrosis) can occur. These reactions have disappeared without treatment. About Merial Merial is a world-leading, innovation-driven animal health company, providing a comprehensive range of products to enhance the health, well-being and performance of a wide range of animals. Merial employs approximately 5,600 people and operates in more than 150 countries worldwide. Its 2011 sales were more than $2.8 billion. Merial is a Sanofi company. For more information, please see www.merial.com.   ®The CATTLE HEAD LOGO is a registered trademark, and ™LONGRANGE and THERAPHASE are trademarks of Merial Limited. ©2012 Merial Limited, Duluth, GA. All rights reserved. RUMIELR1226-A (12/12) 1 Dependent upon parasite species, as referenced in LONGRANGE FOI and product label. 2 Morley FH, Donald AD. Farm management and systems of helminth control. Vet Parasitol. 1980;6:105-134. 3 Brunsdon RV. Principles of helminth control. Vet Parasitol. 1980;6:185-215. 44 LONGRANGE product label. 5 LONGRANGE FOI summary. Available at: http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/USM282157.pdf. Accessed August 27, 2012. 6 Lawrence JD, Ibarburu MA. Economic analysis of pharmaceutical technologies in modern beef production in a bioeconomy era. 2009. Iowa State University. Available at http://www.econ.iastate.edu/faculty/lawrence/Pharma%202007%20update.pdf. Accessed November 13, 2012. 7 Kunkle BN, Williams JC, Johnson EG, et al. Therapeutic and persistent (120-day) duration of efficacy, acceptability and productivity of LONGRANGE when used under field conditions. In Press. 8SAFE-GUARD product label and FOI summary. 9 Corwin RM, Economics of gastrointestinal parasitism of cattle. Vet Parasitol. 1997;72:451-460.

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